第二军医大学本科生论文登顶级期刊

  近日，第二军医大学临床医学2009级本科生王野（Y Wang）撰写的研究论文，在国际权威转化医学期刊、《自然》旗下的《细胞死亡与疾病》杂志发表。该论文在国际上首次提出氧化亚铜纳米粒（Cuprous oxide nanoparticles）可作为临床肿瘤治疗的新型药物，年度SCI影响因子达到6.044分。

    本科生论文能登上顶级医学期刊在全军实属罕见。论文是王野历经四年实验攻关的结晶，部分成果去年发表在国际权威《纳米医学》杂志上，年度SCI影响因子为4.9分。相关课题入选上海市科委基础研究重点项目和上海市教委科研创新项目，成为唯一入选项目的在校本科生。

摘要：Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) selectively induce apoptosis of tumor cells in vitro. To explore the antitumor properties of CONPs in vivo, we used the particles to treat mouse subcutaneous melanoma and metastatic lung tumors, based on B16-F10 mouse melanoma cells, by intratumoral and systemic injections,

respectively. The results showed that CONPs significantly reduced the growth of melanoma, inhibited the metastasis of B16-F10 cells and increased the survival rate of tumorbearing mice. Importantly, the results also indicated that CONPs were rapidly cleared from the organs and that these particles exhibited little systemic toxicity. Furthermore, we observed that CONPs targeted the mitochondria, which resulted in the release of cytochrome C from the mitochondria and the activation of caspase-3 and caspase-9 after the CONPs entered the cells. In conclusion, CONPs can induce the apoptosis of cancer cells through a mitochondrion-mediated apoptosis pathway, which raises the possibility that CONPs could be used to cure melanoma and other cancers.

原文下载：Y Wang, F Yang, H-X Zhang, X-Y Zi, X-H Pan, F Chen, W-D Luo, J-X Li, H-Y Zhu, and Y-P Hu. Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria. Cell Death and Disease, 29 August 2013; doi:10.1038/cddis.2013.314